The best jetting is dependent upon operating altitude.
Plug color will help.
Also, if you are able to discern between balking/hesitation from leanness or blubbering from richness, that is a big indicator.
For the main jet, running wide open throttle, if slightly backed off and it gains speed (slightly closing throttle reduces incoming air, while the main is still sucking about the same), then it is too lean.
For the pilot, if 2 3/4 to maybe 3 turns out on the mixture does not optimize idle, then a larger pilot is needed...or there is a vacuum leak.