Bunchawimps. You oughta ride Hondas or something. Tdub and I did Saginaw TX to Saluda NC via Arlington and Spartanburg, 1028 miles in 22 hours. Stock seat, whiteys, jeans, and mesh gear. Started with a pair of bicycle pants, but they bunched up and hurt--tossed them at the first gas stop. Dumped the luggage on the porch and hit the twisties: Howard Gap Road/Lynn Road//US176/US25/Mountain Summit Road/Terry Creek Road/Greenville Watershed, another 58 miles.
There are strategies to survivng long rides. First, position your butt so that there is just enough forward lean of the upper body so that the wind supports the upper body. This allows muscles to relax and conform, rather than meet force with force. Second, use both sets of pegs, which changes the pressure points. Third, to help maintain speed, tuck on the uphills, left elbow resting on the switch at the base of the left mirror, forearm parallel to the crossbar. This also shifts pressure points, stretches the lower back muscles, and promotes relaxation. Finally, when traffic slows progress, stand up. Change positions often to prolong your riding pleasure.